EVALUATION AND FORMULATION OF LUBEG ( Syzygium lineatum) LEAVES BASED TOPICAL CREAM: A STUDY FOR SUPPLEMENT ANTIMICROBIAL MANAGEMENT AND WOUND HEALING AGAINST STAPHYLOCOCCUS AUREUS AND ESCHERICHIA COLI

Abstract

Escherichia coli and Staphylococcus aureus is one the of the leading causative agent of skin infection worldwide. The Philippine Bureau of Plant Industry promotes Lubeg which has been reported to have a possible antimicrobial activity and wound healing property. The purpose of this study is developed and evaluate the antimicrobial activity and wound healing property of Lubeg Topical Cream against Escherichia coli and Staphylococcus aureus in Sprague Dawley rats a total of 15 rats were divided in three equal groups for the treatment distribution: the negative control group, the positive control group, and the treatment group which received the formulated lubeg topical cream. The lubeg extracts were subjected for microbial assaying to determine the two highest eliciting inhibitory percentage concentrations. The two highest in inbitory effect against Escherichia coli and Staphylococcus aureus is the 75% and 100% Lubeg extract. The two concentration was subjected for the formulation of topical cream. The formulation group, on average had a significant difference in concentration and across time when compared to the positive controls when it comes to its inhibitory effect. While observing the wound healing there is a significant difference between the formulation group and the positive control which post-hoc analysis revealed that the formulation group has a potential wound healing after 14 days of post administration of treatments. Therefore, the Lubeg topical cream can be an antimicrobial supplement management against Staphylococcus aureus and Escherichia coli.